Which of the following conditions can be treated with bisphosphonates?

Bisphosphonates are primarily used to treat conditions related to bone metabolism and density. Paget's disease is a perfect example of a condition that can be effectively managed with bisphosphonates, as these medications work by inhibiting the activity of osteoclasts, the cells that break down bone tissue. This helps to regulate bone remodeling and reduces the excessive bone turnover that characterizes Paget's disease.

The other conditions listed do not benefit from bisphosphonate treatment. Heart failure, chronic respiratory disease, and hypertension involve different physiological systems and mechanisms that are not directly influenced by bisphosphonates, which specifically target bone health. Therefore, the use of bisphosphonates in Paget's disease highlights their role in addressing disorders that affect bone density and integrity.