What is cortisone metabolized into to exert its anti-inflammatory effects?

Cortisone is metabolized into cortisol in the body, and this conversion is crucial for its anti-inflammatory effects. Once cortisone is converted to cortisol, it can bind to glucocorticoid receptors in various tissues, leading to a range of biological responses that help reduce inflammation. Cortisol has a more potent anti-inflammatory effect than cortisone itself and is responsible for many of the therapeutic effects seen in conditions that involve inflammation, such as arthritis and allergic reactions.

The other options do not play a role in this specific metabolism. Adrenaline is a hormone primarily involved in the body's fight-or-flight response and does not have the same anti-inflammatory properties. Estrogen is a hormone primarily involved in reproductive functions and also does not convert from cortisone or play a direct role in inflammation. Insulin is involved in glucose metabolism and has no connection with the metabolism of cortisone into a substance that provides anti-inflammatory effects. Thus, the correct answer emphasizes the critical metabolism of cortisone into cortisol to achieve its intended therapeutic actions.