What does the term immune suppression cell count generally refer to in relation to HIV?

The term immune suppression cell count in relation to HIV typically refers to the measurement of CD4 T lymphocytes in the bloodstream. CD4 cells play a crucial role in the immune system, and their count is a key indicator of the immune status in individuals infected with HIV.

When the CD4 cell count drops to between 200 and 499 cells/mm, it indicates a significant decline in immune function, which increases the risk of opportunistic infections and other complications associated with HIV. This range is crucial for monitoring the progression of HIV infection and determining the need for antiretroviral therapy.

In contrast, a count lower than 200 cells/mm signifies a more severe level of immune suppression, placing the individual at a high risk for opportunistic infections (which is why some might mistakenly consider this also significant). A count above 500 cells/mm is generally regarded as healthier, indicating better immune function, and while a normal range is typically between 500 and 1500 cells/mm, the specific focus on immune suppression aligns more directly with the range of 200 to 499 cells/mm.